enac channel in a sentence
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- However, in the absence of functional CFTR, the ENaC channel is upregulated, and further decreases salt and water secretion by reabsorbing sodium ions.
- Aldosterone initially results in an increase in Na + reabsorption in these patients through stimulation of ENaC channels in principal cells of the renal collecting tubules.
- Increased ENaC channels situated in the apical membranes of the principal cells allow for more Na + reabsorption, which may cause a transient increase in fluid reabsorption as well.
- Studies show that the ENaC channel is permeable to Na + and Li + ions, but has very little permeability to K +, Cs + or Rb + ions.
- Patients with Liddle's syndrome will only respond to a diuretic that binds the ENaC channel, whereas those with AME will respond to a diuretic that binds to ENaC or the mineralcorticoid receptor.
- The proposed mechanism for this phenomenon does not include a reduced sensitivity of mineralocorticoid receptors to aldosterone, because low serum potassium is often seen in these patients, which is the direct result of aldosterone-induced expression of ENaC channels.
- In the absence of chloride flow in cystic fibrosis, sodium ions do not flow through ENaC, leading to greater salt and water loss . ( This is true despite upregulation of the ENaC channel, as flow in the sweat ducts is limited by the electrochemical gradient set up by chloride flow through CFTR . ) As such, patients'skin tastes salty, and this is commonly used to help diagnose the disease, both in the past and today by modern electrical tests.
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